Cardiac Regeneration

Cardiovascular diseases including congenital heart defects are the leading cause of mortality. Cardiac diseases result in myocyte deficiency that ultimately leads to congestive heart failure. Despite significant advances, conventional treatments do not correct the defects in myocyte numbers and the prognosis of congestive heart failure remains poor. For this reason, the replacement of lost cardiomyocytes is a primary target of regenerative medicine research.
Although recent studies have uncovered the remarkable regenerative capacity of the newborn mammalian heart, this regenerative potential is lost shortly after birth, strongly supporting the hypothesis that a detailed understanding of developmental mechanisms is essential to identify targets for cardiac repair or regeneration in congenital and acquired heart diseases. Triggering cell cycle re-entry of existing cardiomyocytes together with the stimulation of multipotent cardiac progenitor cells currently represent the most promising approaches for cardiac regeneration over the coming years.
Using a combination of state of the art molecular, developmental, physiological and transgenic approaches our group aims to enhance our knowledge of cardiac development and to contribute to a greater understanding of regulatory steps controlling cardiomyocyte proliferation and progenitor cell fate. Identifying how these process are regulated is thus of crucial importance in regenerative medicine and will inform future cardiac repair strategies.

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Payan, S.  et al. 2019

Cardiomyocyte proliferation, a target for cardiac regeneration

Cardiac diseases, characterized by cardiomyocyte loss, lead to dramatic impairment of cardiac function and ultimately to congestive heart failure. Despite significant advances, conventional treatments...
Biochim Biophys Acta Mol Cell Res - issue: - volume: - pages: .

Hubert, F.  et al. 2018

FGF10 Signaling in Heart Development, Homeostasis, Disease and Repair

Essential muscular organ that provides the whole body with oxygen and nutrients, the heart is the first organ to function during embryonic development. Cardiovascular diseases, including acquired and...
Front Genet - issue: - volume: 9 - pages: 599.

Ahles, A.  et al. 2015

Interhelical Interaction and Receptor Phosphorylation Regulate the Activation Kinetics of Different Human beta(1)-Adrenoceptor Variants

G protein-coupled receptors represent the largest class of drug targets, but genetic variation within G protein-coupled receptors leads to variable drug responses and, thereby, compromises their...
J. Biol. Chem. - issue: 3 - volume: 290 - pages: 1760-1769.

Rochais, F.  et al. 2014

FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry

AIMS: Cardiomyocyte proliferation gradually declines during embryogenesis resulting in severely limited regenerative capacities in the adult heart. Understanding the developmental processes...
Cardiovasc. Res. - issue: 3 - volume: 104 - pages: 432-442.

Ahles, A.  et al. 2011

A polymorphism-specific "memory" mechanism in the β(2)-adrenergic receptor

Signaling through G protein (heterotrimeric guanosine triphosphate-binding protein)-coupled receptors is affected by polymorphisms in receptor-encoding genes. Using fluorescence resonance energy...
Sci Signal - issue: 185 - volume: 4 - pages: ra53.

Rochais, F.  et al. 2010

Acute cardiac effects of neuregulin-1/ErbB signalling


Cardiovasc. Res. - issue: 3 - volume: 88 - pages: 393-394.