CONTEXT: Somatostatin receptor ligands (SRLs) are the cornerstone medical treatments for acromegaly, however many patients remain unresponsive to SRLs. Well-established predictive markers of response...
J Clin Endocrinol Metab - issue: - volume: - pages: dgac512.

The desmopressin test was first described 30 years ago. Based on the differential secretagogue properties of desmopressin on ACTH release between normal and corticotroph tumor cells, this test was...
J Clin Endocrinol Metab - issue: - volume: - pages: dgac533.

Recurrent or high-grade meningiomas are an unmet medical need. Recently, we demonstrated that targeting mTOR by everolimus was relevant both in vitro and in humans. However, everolimus induces an AKT...
Cancers (Basel) - issue: 18 - volume: 14 - pages: .

OBJECTIVE: The Treatment of Brain Arteriovenous Malformations Study (TOBAS) is a pragmatic study that includes 2 randomized trials and registries of treated or conservatively managed patients. The...
J Neurosurg - issue: - volume: - pages: 1-9.

PURPOSE: The efficacy of levoketoconazole for endogenous Cushing's syndrome was demonstrated in a phase 3, open-label study (SONICS). This study (LOGICS) evaluated drug-specificity of cortisol...
Pituitary - issue: - volume: - pages: .

Transsphenoidal surgery is the first-line treatment for acromegaly. However, several factors can modify surgical remission rates, such as the initial hormone levels, the size and invasiveness of the...
J Endocr Soc - issue: 9 - volume: 6 - pages: bvac114.

Congenital hypopituitarism is a genetically heterogeneous condition that is part of a spectrum disorder that can include holoprosencephaly. Heterozygous mutations in SIX3 cause variable...
Hum Mol Genet - issue: - volume: - pages: ddac192.

Craniopharyngiomas (CPs) are rare tumors of the skull base, developing near the pituitary gland and hypothalamus and responsible for severe hormonal deficiencies and an overall increase in mortality...
Cancers (Basel) - issue: 15 - volume: 14 - pages: .

Somatostatin receptor (SSTR)-targeted peptide receptor radionuclide therapy (PRRT) represents a promising approach for treatment-refractory meningiomas progressing after surgery and radiotherapy. The...
Curr Oncol - issue: 8 - volume: 29 - pages: 5550-5565.

Transsphenoidal surgery is the first-line treatment of Cushing's disease. However, medical treatment can be given in a high proportion of patients with this rare condition. This is especially the...
J Neuroendocrinol - issue: 8 - volume: 34 - pages: e13120.

Pigmented epithelioid melanocytoma is a rare cutaneous melanocytic proliferation considered high-grade melanocytoma in the 2018 WHO Classification of Skin Tumors. Little has been reported about the...
Am J Surg Pathol - issue: 8 - volume: 46 - pages: 1106-1115.

BACKGROUND: SDHB is one of the major genes predisposing to paraganglioma/pheochromocytoma (PPGL). Identifying pathogenic SDHB variants in patients with PPGL is essential to the management of patients...
J Med Genet - issue: 8 - volume: 59 - pages: 785-792.

PURPOSE: Measurement of prolactin in clinical laboratories is an important component in the management of patients with pituitary adenoma. Prolactin measurement is known to be sensitive to the...
Pituitary - issue: 4 - volume: 25 - pages: 653-657.

The implementation of high-throughput diagnostic sequencing has led to the generation of large amounts of mutational data, making their interpretation more complex and responsible for long delays. It...
Int J Mol Sci - issue: 15 - volume: 23 - pages: 8506.

Exon skipping is a promising therapeutic approach. One important condition for this approach is that the exon-skipped form of the gene can at least partially perform the required function and lead to...
Genes (Basel) - issue: 7 - volume: 13 - pages: 1277.

INTRODUCTION: Pancreatic neuroendocrine neoplasms (PNENs) present with a fibrotic stroma that constitutes the tumor microenvironment (TME). The role played by stromal fibroblasts in the growth of...
Cancers (Basel) - issue: 14 - volume: 14 - pages: .

CONTEXT: Ectopic acromegaly is a consequence of rare neuroendocrine tumors (NETs) that secrete GHRH. This abnormal GHRH secretion drives GH and IGF-1 excess, with a clinical presentation similar to...
J Clin Endocrinol Metab - issue: 8 - volume: 107 - pages: e3313-e3320.

The mammalian heart arises from various populations of Mesp1-expressing cardiovascular progenitors (CPs) that are specified during the early stages of gastrulation. Mesp1 is a transcription factor...
Nat Cell Biol - issue: - volume: - pages: Epub ahead of print.

Histopathology - issue: 1 - volume: 81 - pages: 133-137.

Background: Genetic cardiac diseases are the main trigger of sudden cardiac death (SCD) in young adults. Hypertrophic cardiomyopathy (HCM) is the most prevalent cardiomyopathy and accounts for 0.5 to...
Mol Genet Genomic Med - issue: 7 - volume: 10 - pages: e1954.